Tupac and Biggie were close friend until the shooting occur. Tupac claimed that Biggie set him up. When Biggie came out with his album it was very similar to Pac's upcoming album Tupac was very angered by this and had to change the whole album which it was "Me Against The World". Pac said that, Biggie was rapping about his life style, pac also mentioned that all the guns charge he face in court was Biggie and his boys guns. Pac said they left it in my house and run like a coward but I didn't even snitch them out.

The fugees

This started when Fugees talking about what Tupac says in the interviews and to the press. The Fugees said "who shot Ya" on one of their album since then Pac started to hate The fugess. When the press asked Pras if he really believes Tupac is dead. Pras responded saying, "As dead as a door-knob." In any case, due to the uncalled for shots, in Tupac tradition, he retaliated with the unreleased record "When We Ride On Our Enemies."

LL cool J

On Me Against The World Tupac was giving props to LL in "Old School" Tupac reason being was that Pac was listening to it in the old days (1986)." But when the Mobb Deep beef began, LL took Mobb Deep's side. Plus LL cool J had a track called "I Shot Ya, " which giving Mobb Deep props for dissing Tupac.

Mobb Deep

When the song "New York, New York" by the Dogg Pound was released, which they were dissing NY. A lot of beef started when the video came out, when the video making took place in NY in which a car drove up and shot up the place. Tragedy and Capone N Noreaga released "LA, LA, the video showed stand-ins for the dog pound being kidnapped and tortured, and getting tossed on the NY street." Prodigy said, On the record, "Crime Pays "Came to California, my crew loadin nines, screamin now its past your time, on the border (Vegas) where we stood, anxiously awaiting your richous crooks, (Havoc from Mobb Deep) slammed the door of the caddy, blaze the blunt & load the daddy, drove past your fuckin sign, what was yours suddenly became mine, shattered the window with the nine, killin bitches is a must, not a crime." Tupac got mad to what they were saying on the chorus of the song and dissed them back on "Hit Um Up" by saying " Don't one of you niggas got sickle-cell you gonna fuck around and have a seizure".

Jay-Z

Jay-Z dissed Tupac on the record, "Brooklyn's Finest, " featuring Biggie. On the same track, Biggie dissed Tupac as well. Aside from "Brooklyn's Finest, " Jay-Z attacked Tupac for dissing Mobb Deep. "Bomb First" was then written and recorded on the album Don Killuminati: Seven Day Theory, which Tupac attacks back at Jay-Z and others rivals. Plus Jaz-y was close friends with the Bad Boy family since they were all from Brooklyn.

Chino XL

Chino XL on one of his song from his album "Hear To Save You All" in which he dissed everyone from Whitney Houston to Eddie Murphy to the Hieroglyphics and to Tupac. But knowing Tupac there is going to be pay back.

Dr.Dre

When Dre left Death Row, Tupac hated Dre just for leaving Death Row and that did he never showed up for Snoop Dogg hearings. Tupac said that Dre was getting to much credit for the work he never actually did. Dre said nothing against Tupac's words.

Dan quayle

He was the Vice president in a political. He wanted to ban 2pac's albums. 2pac ended up saying "Dan quayle can Eat a dick up". Same thing been said to Bob Dole, dole said he wanted to ban Gangsta Rap.

Nas

Tupac didn't like reason being was Nas was taking his beats from "All Eyez On Me". Tupac said Nas was using some of his styles.